ToDAY (cephapirin sodium)

This treatment applies to the following species:

Dairy Cattle

Company: Boehringer Ingelheim Animal Health

cephapirin sodium

Approved by FDA under NADA # 097-222

FOR INTRAMAMMARY INFUSION

ToDAY (cephapirin sodium) Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description

ToDAY (cephapirin sodium) is a cephalosporin which possesses a wide range of antimicrobial activity against gram-positive and gram-negative organisms. It is derived biosynthetically from 7-aminocephalosporanic acid.

Each 10 mL disposable syringe contains 200 mg of cephapirin activity in a stable peanut oil gel. This product was manufactured by a non-sterilizing process.

Store at or below 25°C (77°F). Do not freeze. Avoid excessive heat.

Action

Cephapirin is bactericidal to susceptible organisms; it is known to be highly active against Streptococcus agalactiae and Staphylococcus aureus including strains resistant to penicillin.

To determine the susceptibility of bacteria to cephapirin in the laboratory, the class disc, Cephalothin Susceptibility Test Discs, 30 mcg, should be used.

ToDAY (cephapirin sodium) Indications

FOR LACTATING COWS ONLY / For the Treatment of Bovine Mastitis

ToDAY (cephapirin sodium) for Intramammary Infusion should be used at the first signs of inflammation or at the first indication of any alteration in the milk. Treatment is indicated immediately upon determining, by C.M.T. or other tests, that the leukocyte count is elevated, or that a susceptible pathogen has been cultured from the milk.

ToDAY for Intramammary Infusion has been shown to be efficacious in the treatment of mastitis in lactating cows caused by susceptible strains of Streptococcus agalactiae and Staphylococcus aureus including strains resistant to penicillin.

Dosage And Directions For Use

Infuse the entire contents of one syringe (10 mL) into each infected quarter immediately after the quarter has been completely milked out. Repeat once only in 12 hours. If definite improvement is not noted within 48 hours after treatment, the causal organism should be further investigated. Consult your veterinarian.

Milk out udder completely. Wash the udder and teats thoroughly with warm water containing a suitable dairy antiseptic and dry, preferably using individual paper towels. Carefully scrub the teat end and orifice with 70% alcohol, using a separate swab for each teat. Allow to dry.

ToDAY (cephapirin sodium) is packaged with the Opti-Sert^® Protective Cap.

For partial insertion: Twist off upper portion of the Opti-Sert Protective Cap to expose 3-4 mm of the syringe tip.

For full insertion: Remove protective cap to expose the full length of the syringe tip.

Insert syringe tip into the teat canal and expel the entire contents of one syringe into each infected quarter. Withdraw the syringe and gently massage the quarter to distribute the suspension into the milk cistern. Do not milk out for 12 hours.

Do not infuse contents of the mastitis syringe into the teat canal if the Opti-Sert Protective Cap is broken or damaged.

Reinfection - The use of antibiotics, however effective, for the treatment of mastitis will not significantly reduce the incidence of this disease in the herd unless their use is fortified by good herd management, and sanitary and mechanical safety measures are practiced to prevent reinfection.

Precautions

ToDAY should be administered with caution to subjects which have demonstrated some form of allergy, particularly to penicillin. Such reactions are rare; however, should they occur, consult your veterinarian.

RESIDUE WARNINGS

1. Milk that has been taken from animals during treatment and for 96 hours after the last treatment must not be used for food.

2. Treated animals must not be slaughtered for food until 4 days after the last treatment.

3. Administration of more than the prescribed dose may lead to residue of antibiotic in milk longer than 96 hours.

HOW SUPPLIED

ToDAY (cephapirin sodium) for Intramammary Infusion. Cephapirin sodium equivalent to 200 mg of cephapirin activity per syringe.

Each pail contains 144 x 10 mL syringes and 144 convenient single use alcohol pads. NDC 0010-4754-02.

ToDAY is also supplied in cartons containing 12 x 10 mL syringes with 12 convenient single use alcohol pads. NDC 0010-4754-01.

Not for Human Use

ToDAY is a registered trademark of Boehringer Ingelheim Animal Health USA Inc.

Opti-Sert is a registered trademark of Zoetis W LLC - used under license.

Origin China

Marketed by:

Boehringer Ingelheim Animal Health USA Inc., Duluth, GA 30096

471701-03

Revised 07/2022

51750384

CPN: 1028223.4

BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
3239 SATELLITE BLVD., BLDG 500, DULUTH, GA, 30096

Telephone:		800-325-9167
Customer Service:		888-637-4251
Technical Service:		888-637-4251
Fax:		816-236-2717
Website:		www.boehringer-ingelheim.com

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