MU-SE Injectable (Canada)

Injectable

VETERINARY USE ONLY

DIN 00518654

Description

MU-SE is an emulsion of selenium-tocopherol for the prevention and treatment of Selenium-Tocopherol Deficiency (STD) syndrome in weanling calves and breeding beef cows. Each mL contains: Active ingredients: Selenium (as sodium selenite) 5 mg, Vitamin E (as d-alpha tocopheryl acetate, USP) 68 IU. Preservative: benzyl alcohol 0.02 mL (2 % v/v). Inactive ingredients: polysorbate-80 250 mg, water for injection q.s. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH.

Pharmacology

It has been demonstrated that selenium and tocopherol exert physiological effects and that these effects are intertwined with sulfur metabolism. Additionally, tocopherol appears to have a significant role in the oxidation process, thus suggesting an interrelationship between selenium and tocopherol in overcoming sulfur-induced depletion and restoring normal metabolism. Although oral ingestion of adequate amounts of selenium and tocopherol would seemingly restore normal metabolism, it is apparent that the presence of sulfur and, perhaps, other factors interfere with the proper utilization of selenium and tocopherol during the digestive process. When selenium and tocopherol are injected, they bypass the digestive process and exert their full metabolic effects promptly on cell metabolism.

MU-SE Injectable Indications

MU-SE is recommended for the prevention of Selenium-Tocopherol Deficiency (STD) syndrome in weanling calves and breeding beef cows. Clinical signs are: stiffness and lameness; chronic, persistent diarrhea; unthriftiness; abortions and/or weak premature calves.

Warnings

Treated animals must not be slaughtered for use in food for at least 30 days after the latest treatment with this drug. Do not use in lactating dairy cattle.

MU-SE Injectable Caution

Selenium is toxic if administered in excess. A fixed dose schedule is therefore important (read package insert for each selenium-tocopherol product carefully before using).

Selenium-Tocopherol Deficiency (STD) syndrome produces a variety and complexity of symptoms often interfering with a proper diagnosis. Even in selenium deficient areas there are other disease conditions which produce similar clinical signs. It is imperative that all these conditions be carefully considered prior to treatment of STD syndrome. Elevated SGOT and creatinine levels may serve as aids in arriving at a diagnosis of STD, when associated with other indices.

Important: Use only the selenium-tocopherol product recommended for each species. Each formulation is designed for the species indicated to produce maximum efficacy and safety.

Adverse Reactions

Anaphylactoid reactions, some of which have been fatal, have been reported in cattle administered the MU-SE product. Signs include excitement, sweating, trembling, ataxia, respiratory distress, and cardiac dysfunction. Premature births and abortions have been reported in cattle injected with this product during the third trimester of pregnancy.

MU-SE Injectable Dosage And Administration

Inject subcutaneously or intramuscularly. Weanling Calves, 1 mL per 90 kg of body weight. Breeding Beef Cows, 1 mL per 90 kg of body weight during the middle third of the pregnancy and 30 days before calving.

How Supplied

Sterile, multiple dose vials. 100 mL and 250 mL.

Storage

Store between 2° and 25°C. Protect from freezing.

Intervet Canada Corp., subsidiary of Merck & Co., Inc., Kirkland, Quebec H9H 4M7

866-683-7838

^® Registered trademark of Merck Sharp & Dohme Corp. Used under license.

Ver 27FEB2013

CPN: 1208061.6