Tacrolimus (International)
In the US, Tacrolimus (tacrolimus systemic) is a member of the drug class calcineurin inhibitors and is used to treat Crohn's Disease, Graft-versus-host disease, Nephrotic Syndrome, Organ Transplant - Rejection Prophylaxis and Organ Transplant - Rejection Reversal.
US matches:
- Tacrolimus oral and injection
- Tacrolimus topical
- Tacrolimus (Intravenous)
- Tacrolimus (Oral)
- Tacrolimus (Topical)
- Tacrolimus
- Tacrolimus 0.03% Ointment
- Tacrolimus 0.1% Ointment
- Tacrolimus Capsules
- Tacrolimus Extended-Release Capsules
- Tacrolimus Extended-Release Tablets
- Tacrolimus Granules for Suspension
- Tacrolimus Injection
- Tacrolimus ER Capsules
- Tacrolimus Ointment
Scheme
Rec.INN
ATC (Anatomical Therapeutic Chemical Classification)
D11AH01,L04AA05,L04AD02
CAS registry number (Chemical Abstracts Service)
0104987-11-3
Chemical Formula
C44-H69-N-O12
Molecular Weight
804
Therapeutic Category
Immunosuppressant
Chemical Name
Immunosuppreβant derived from Streptomyces tsukubaensis
Foreign Names
- Tacrolimusum (Latin)
- Tacrolimus (German)
- Tacrolimus (French)
- Tacrolimus (Spanish)
Generic Names
- Tacrolimus (OS: USAN, BAN)
- Tacrolimus (PH: USP 41)
- Tacrolimus Hydrate (OS: JAN)
- FK 506 (Fujisawa) (IS)
- FR 900506 (IS)
- L 683590 (IS)
- Tacrolimus Hydrate (PH: JP XVII)
- Tacrolimus Monohydrate (PH: BP 2018, Ph. Eur. 9.3)
Brand Names
- Adoport
Lek, Slovenia - Adoport 0,5 mg
Sandoz, Turkey - Adoport 1 mg
Sandoz, Turkey - Adoport 5 mg
Sandoz, Turkey - Advagraf
Astellas, Bosnia & Herzegowina; Astellas, Canada; Astellas, Estonia; Astellas, Georgia; Astellas, Hong Kong; Astellas, Croatia (Hrvatska); Astellas, Iceland; Astellas, Italy; Astellas, Latvia; Astellas, Norway; Astellas, Philippines; Astellas, Portugal; Astellas, Romania; Astellas, Russian Federation; Astellas, Slovakia; Astellas, Taiwan; Astellas, South Africa; Astellas Pharma, Poland; Astellas Pharma, Serbia; Astellas Pharma China, China; Astellas Pharma Europe, Netherlands; Astellas Pharma Europe BV, Greece; DKSH, Malaysia - Advagraf 0,5 mg
Astellas, Turkey - Advagraf 0,5 mg retard
Astellas, Hungary - Advagraf 0.5mg
Astellas, Switzerland - Advagraf 1 mg
Astellas, Turkey - Advagraf 1 mg retard
Astellas, Hungary - Advagraf 1mg
Astellas, Switzerland - Advagraf 3 mg retard
Astellas, Hungary - Advagraf 3mg
Astellas, Switzerland - Advagraf 5 mg
Astellas, Turkey - Advagraf 5 mg retard
Astellas, Hungary; Astellas Pharma, Germany - Advagraf 5mg
Astellas, Switzerland - Advagraf LP
Hikma, Tunisia - Advagraf PR
Astellas Pharma, Cyprus - Advagraf Prolonged Release
Astellas, Slovenia - Advagraf XL
Astellas Pharma, Australia - Astagraf XL
Astellas, United States - Atolimus
Beximco, Bangladesh - Cellmune 0.1%
Industrial Farmaceutica Cantabria, United Kingdom - Cidimus
Novartis, Chile; Sandoz, Poland - Cromus
Procaps, Colombia - Cromus Ung
Unimed, Peru - Dermitopic 0.1%
Pharmaswiss Ceska Republika, United Kingdom - Effac
Meider, Taiwan - Envarsus
Chiesi, Greece; Chiesi, Lithuania; Chiesi Farmaceutici, Slovenia; Chiesi Pharmaceuticals, Bosnia & Herzegowina; Chiesi Pharmaceuticals, Poland; Providens, Croatia (Hrvatska) - Envarsus 0.75 mg retard
Chiesi, Hungary - Envarsus 1 mg retard
Chiesi, Hungary - Envarsus LP
Chiesi, France - Envarsus XR
Veloxis Pharmaceuticals, United States - Gecrol
Heaton, Czech Republic; Heaton, Slovakia - Imugraft 0.5
Ambica, Philippines - Lecron
PharOS, Italy - Limus
Alco, Bangladesh - Modigraf
Astellas, Lithuania; Astellas, Slovenia; Astellas, Slovakia; Astellas Pharma, Germany; Astellas Pharma, Denmark; Astellas Pharma Europe, Iceland; Orifarm, Norway - Modigraf 0.2 mg
Astellas, Switzerland; Astellas, Hungary - Modigraf 1 mg
Astellas, Hungary - Modigraf 1mg
Astellas, Switzerland - Mustopic
Systopic, India - Norgraf
Nordic, Peru - Oligma
Eczacibasi Ilac Pazarlama, Turkey - Pacrolim
Alphapharm, Australia - Panolimus
Biem, Turkey - Proalid
Italmex, Mexico - Prodermic
Iqfarma, Peru - Produke
Titan, Georgia - Produke SR
Titan, Georgia - Prograf
Astellas, Bosnia & Herzegowina; Astellas, Canada; Astellas, Czech Republic; Astellas, Egypt; Astellas, Georgia; Astellas, Greece; Astellas, Hong Kong; Astellas, Indonesia; Astellas, Israel; Astellas, Italy; Astellas, South Korea; Astellas, Macedonia; Astellas, Malta; Astellas, Philippines; Astellas, Portugal; Astellas, Sweden; Astellas, Slovakia; Astellas, Thailand; Astellas, Turkey; Astellas, Taiwan; Astellas, United States; Astellas, South Africa; Astellas Pahrmaceuticals Aebe, Cyprus; Astellas Pharma, Australia; Astellas Pharma, Denmark; Astellas Pharma, United Kingdom; Astellas Pharma, Poland; Astellas Pharma, Singapore; Astellas Pharma a/s, Iceland; Astellas Pharma China, China; Astellas Pharma Europe, Romania; Astellas Pharma Singapore, Vietnam; DKSH, Malaysia; Farmagon, Norway; Gador, Argentina; Gador, Chile; Gador, Paraguay; Hikma, Kuwait; Hikma, Lebanon; Hikma, Oman; Hikma, Tunisia; Janssen, Venezuela; Janssen-Cilag, Brazil; Orifarm, Norway - Prograf 0.5 mg
Astellas, Hungary - Prograf 0.5mg
Astellas, Switzerland; Astellas, Israel; Gador, Uruguay - Prograf 1 mg
Astellas, Hungary - Prograf 1mg
APS, Switzerland; Astellas, Switzerland; Astellas, Israel - Prograf 5 mg
Astellas, Hungary - Prograf 5 mg/ml
Astellas, Hungary - Prograf 5mg
Astellas, Switzerland; Astellas, Israel; Gador, Uruguay - Prograf 5mg/ml
Astellas, Switzerland; Astellas Pharma, Austria; Astellas Pharma, Germany - Prograf XL
Astellas Pharma, Australia; Gador, Argentina; Gador, Chile - Protopic
Astellas, Georgia; Astellas, Greece; Astellas, Hong Kong; Astellas, Italy; Astellas, Portugal; Astellas, Taiwan; Astellas Ireland, Serbia; Astellas Pharma China, China; Janssen, Malaysia; Janssen, Philippines; Janssen, Singapore; Janssen-Cilag/Astellas, Indonesia; LEO, Norway; LEO Pharma, Canada; LEO Pharma, Greece; LEO Pharma, Lithuania; LEO Pharma, Latvia; LEO Pharma, Turkey; LEO Pharma, United States; Leofarma, Brazil; Roche Uruguay, Uruguay - Protopic 0.01%
Astellas, Croatia (Hrvatska) - Protopic 0.03%
Astellas, Switzerland; Astellas, Croatia (Hrvatska); Astellas, Israel; Astellas Pharma, Cyprus; Astellas Pharma, Poland; LEO Pharma, Spain; LEO Pharma, Netherlands - Protopic 0.1%
Astellas, Israel; Astellas Pharma, Cyprus; LEO Pharma, Switzerland; LEO Pharma, Netherlands; Leo Pharma A/S, Iceland - Protopy
Astellas, Lithuania - Regraf
MMC, Georgia - Remus
Square, Bangladesh - Rocimus
Mega Lifesciences, Philippines - Seegraf
Micro Labs, India - Tacloran
Wockhardt, India - Tacni
Pliva, Bosnia & Herzegowina; Pliva, Croatia (Hrvatska); Teva, Czech Republic; Teva, Spain; Teva, Greece; Teva, Lithuania; Teva, Norway; Teva Pharma, Cyprus; Teva Pharma, Slovenia; Teva Pharmaceuticals, Poland - Tacni 0.5mg
ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland - Tacni 1mg
ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland - Tacni 5mg
ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland - Tacpan 0,5mg
Panacea Biotec Germany, Germany - Tacpan 1mg
Panacea Biotec Germany, Germany - Tacpan 5mg
Panacea Biotec Germany, Germany - Tacroderm
AHPL, India - Tacrograf
Biocon, India - Tacrol
Acme, Bangladesh - Tacroli
Hwang's, Taiwan - Tacrolim
Incepta, Bangladesh - Tacrolimus
Accord Healthcare, United States; Belcher Pharmaceuticals, United States; Dr. Reddy's, United States; Fougera, United States; Hospira, United States; Lek, Bosnia & Herzegowina; Mylan, United States; Panacea Biotec, United States; Sandoz, United States; Strides Pharma, United States - Tacrolimus Accord
Accord, Lithuania; Accord Healthcare, Poland - Tacrolimus Accord 0.1%
Accord Healthcare, United Kingdom - Tacrolimus Accord Healthcare
Accord Healthcare, Italy - Tacrolimus Cinfa
Cinfa, Spain - Tacrolimus Medis
Medis, Tunisia - Tacrolimus Mylan
Mylan, Spain - Tacrolimus Pharma Arte
Pharma Arte, Paraguay - Tacrolimus PharmaSwiss
PharmaSwiss, Estonia; PharmaSwiss, Lithuania - Tacrolimus Pierre Fabre 0.1%
Pierre Fabre, United Kingdom - Tacrolimus Sandoz
Novartis, New Zealand; Sandoz, Hong Kong - Tacrolimus Servimedic
Servimedic, Uruguay - Tacrolimus Stada
STADA, Spain - Tacrolimus Teva 0.1%
Teva Pharmaceuticals, United Kingdom - Tacrolin
Farma-Tek, Turkey - Tacromus
Zydus Cadila, India - Tacrotec
Marzan Pharma, Philippines - Tacrotopic
Lafedar, Argentina - Tacroz
Glenmark, Ecuador; Glenmark, India; Glenmark Pharmaceuticals, Vietnam - Tacroz Forte
Glenmark, Ecuador; Glenmark, India; Glenmark, Peru; Glenmark Pharmaceuticals, Vietnam - Tagraf
Panacea Biotech, Philippines - Takrocept
Intas, Poland - Takrolimus Belupo
Belupo, Croatia (Hrvatska) - Takrolimus Genera
Genera, Croatia (Hrvatska) - Takrolimus Sandoz
Lek, Serbia - Taliximun
PharmaSwiss, Poland - Tames
Olcare Laboratories, India - Tarfic
Libbs, Brazil - Tarolimus 0.03%
Andalous, Egypt - Tartrime
Gobbi-Novag, Argentina; Juste, Spain - T-Inmun
Complex Therapeutics, Chile; Mediderm, Chile; Recalcine, Ecuador; Recalcine, Paraguay - Topgraf
GlaxoSmithKline, India - Topiclin
Solebio, Turkey - Tracsus
Alvogen, Croatia (Hrvatska); Alvogen Luxembourg, Romania; Cinfa, Macedonia; Laboratorios Cinfa, Bosnia & Herzegowina - Traderma
Serral, Mexico - T-Top
Wallace, India - T-Top Forte
Wallace, India - Vingraf
Emcure Pharma, Philippines - Adoport
Sandoz, Belgium; Sandoz, Portugal; Sandoz España, Spain - Adoport 0,5 mg
Sandoz, France; Sandoz, United Kingdom - Adoport 0.75 mg
Sandoz, United Kingdom - Adoport 1 mg
Sandoz, France; Sandoz, United Kingdom - Adoport 2 mg
Sandoz, France; Sandoz, United Kingdom - Adoport 5 mg
Sandoz, France; Sandoz, United Kingdom - Adport
Sandoz, Denmark; Sandoz, Georgia; Sandoz, Netherlands; Sandoz, Sweden - Adport 0,5 mg
Sandoz, Austria - Adport 1 mg
Sandoz, Austria - Adport 2 mg
Sandoz, Austria - Adport 5 mg
Sandoz, Austria - Advagraf
Astellas, Czech Republic; Astellas, Spain; Astellas, Finland; Astellas, Ireland; Astellas, South Korea; Astellas, Lithuania; Astellas, Sweden; Astellas, Thailand; Astellas Pharma, Belgium; Astellas Pharma, Denmark; Astellas Pharma, Singapore; Astellas Pharma Singapore, Vietnam - Advagraf 0,5 mg
Astellas, France - Advagraf 0,5 mg retard
Abacus, Austria; Astellas Pharma, Germany; Astellas Pharma Europe, Austria; Haemato Pharm, Austria - Advagraf 0.5mg
Astellas, Israel - Advagraf 0.5mg prolonged-release
Astellas Pharma, United Kingdom - Advagraf 1 mg
Astellas, France - Advagraf 1 mg prolonged-release
Astellas Pharma, United Kingdom - Advagraf 1 mg retard
Astellas Pharma, Germany; Astellas Pharma Europe, Austria - Advagraf 3 mg prolonged-release
Astellas Pharma, United Kingdom - Advagraf 3 mg retard
Astellas Pharma, Germany - Advagraf 3mg
Astellas, France - Advagraf 5 mg
Astellas, France - Advagraf 5 mg prolonged-release
Astellas Pharma, United Kingdom - Advagraf 5 mg retard
Abacus, Austria; Astellas Pharma Europe, Austria; Emra-Med Arzneimittel, Austria - Advagraf-0.5
Astellas, Luxembourg - Advagraf-1
Astellas, Luxembourg - Advagraf-3
Astellas, Luxembourg - Advagraf-5
Astellas, Luxembourg - Crilomus
Hexal, Germany - Crilomus 0.5mg
Sandoz, Switzerland - Crilomus 0.75mg
Sandoz, Switzerland - Crilomus 1mg
Sandoz, Switzerland - Crilomus 2mg
Sandoz, Switzerland - Crilomus 5mg
Sandoz, Switzerland - Dermitopic 0.1%
PharmaSwiss, Poland - Envarsus
Chiesi, Czech Republic; Chiesi, Germany; Chiesi, Denmark; Chiesi, Estonia; Chiesi, Spain; Chiesi, United Kingdom; Chiesi, Ireland; Chiesi, Norway; Chiesi, Sweden; Chiesi Farmaceutici, Netherlands; Chiesi Pharma, Finland - Envarsus 0.75mg
Chiesi, Switzerland; Chiesi Farmaceutici, Austria - Envarsus 1mg
Chiesi, Switzerland; Chiesi Farmaceutici, Austria - Envarsus 4mg
Chiesi, Switzerland; Chiesi Farmaceutici, Austria - Framebin
Pisa, Mexico - Graceptor
Astellas, Japan - Limustin
Landsteiner, Mexico - Modigraf
Astellas, Czech Republic; Astellas, Estonia; Astellas, Spain; Astellas, Finland; Astellas, France; Astellas, Ireland; Astellas, Latvia; Astellas, Norway; Astellas, Sweden; Astellas Pharma, United Kingdom; Astellas Pharma, Poland; Astellas Pharma Europe, Netherlands - Modigraf 0,2mg
Astellas Pharma Europe, Austria - Modigraf 1mg
Astellas Pharma Europe, Austria - Octralin
Raam, Mexico - Pharmacor Tacrolimus
Pharmacor, Australia - Prograf
Astellas, Bulgaria; Astellas, Spain; Astellas, Finland; Astellas, France; Astellas, Croatia (Hrvatska); Astellas, Ireland; Astellas, Japan; Astellas, South Korea; Astellas, Malta; Astellas, Norway; Astellas, Sweden; Astellas Ireland, Serbia; Astellas Pharma, United Kingdom; Janssen-Cilag, Mexico - Prograf 0,5mg
Astellas Pharma, Austria; Astellas Pharma, Germany - Prograf 1mg
Astellas Pharma, Austria; Astellas Pharma, Germany - Prograf 5mg
Astellas Pharma, Austria; Astellas Pharma, Germany - Prograf XL
Janssen-Cilag, Mexico - Prograft
Astellas, Belgium; Astellas Pharma Europe, Netherlands; BModesto, Netherlands; Delphi, Netherlands; Dr. Fisher Farma, Netherlands; EU-Pharma, Netherlands; Euro Registratie, Netherlands; Medcor Pharmaceuticals, Netherlands - Prograft-0.5
Astellas, Luxembourg - Prograft-1
Astellas, Luxembourg - Prograft-5
Astellas, Luxembourg - Protopic
Astellas, South Korea; Astellas, South Africa; Hikma, Oman; Janssen, Thailand; LEO, Ireland; LEO Pharma, Czech Republic; LEO Pharma, Denmark; LEO Pharma, Estonia; LEO Pharma, Finland; LEO Pharma, Sweden; Productos Roche, Chile; Roche, Ecuador; Roche, Mexico - Protopic 0.03%
Astellas, Japan; Astellas, Slovakia; Eurim-Pharm, Austria; LEO, Germany; LEO Laboratories, United Kingdom; Leo Pharma, Austria; Leo Pharma, Belgium; Leo Pharma, Finland; Leo Pharma, France; Leo Pharma, Hungary; Leo Pharma, Luxembourg; Leo Pharma, Romania - Protopic 0.1%
Astellas, Japan; Astellas, Slovakia; Astellas Pharma, Poland; Eurim-Pharm, Austria; LEO, Germany; LEO Laboratories, United Kingdom; Leo Pharma, Austria; Leo Pharma, France; Leo Pharma, Hungary; Leo Pharma, Luxembourg; Leo Pharma, Romania - Sandoz Tacrolimus
Sandoz, Canada - Tacforius
Teva Nederland, Netherlands - Tacni
Pharmachemie, Netherlands; Teva, Sweden - Tacrobell
Chong Kun Dang, South Korea - Tacrocel
Sandoz, Croatia (Hrvatska) - Tacrocel 0.5mg
LEK Pharmaceuticals, Israel - Tacrocel 1mg
LEK Pharmaceuticals, Israel - Tacrocel 5mg
LEK Pharmaceuticals, Israel - Tacrocin
Intas, Philippines - Tacroderm
Lazar, Argentina - Tacrolimus
Ayumi Pharmaceutical, Japan; Mylan Seiyaku, Japan; Nichi-Iko Pharmaceutical, Japan; Nihon Generic, Japan; Nipro, Japan; Sandoz, Argentina; Sandoz, Georgia; Towa Yakuhin, Japan; Nipro Pharma Nipurofama, Japan - Tacrolimus 0.1%
Iwaki Seiyaku, Japan; Pola Pharma, Japan; Takata Pharmaceutical, Japan; Nipro Pharma Nipurofama, Japan - Tacrolimus Accord
Accord Healthcare, Netherlands; Lyomark Pharma, Germany - Tacrolimus AL
Aliud Pharma, Germany - Tacrolimus Apotex
Pharmacor, Australia - Tacrolimus CF
Centrafarm, Netherlands - Tacrolimus Heumann
Heumann, Germany - Tacrolimus HEXAL
Hexal, Germany - Tacrolimus Lek
LEK farmacevtska, Macedonia - Tacrolimus Pergamus
Accord Healthcare, Bulgaria; Actavis, Bulgaria - Tacrolimus Sandoz
Sandoz, Australia; Sandoz, Netherlands; Sandoz, Romania; STADA, Spain - Takrozem
Pierre Fabre, Netherlands - Talymus 0.1%
Senju Seiyaku, Japan - Tarimus
Hanmi, South Korea
Glossary
| Term | Definition |
|---|---|
| BAN | British Approved Name |
| IS | Inofficial Synonym |
| JAN | Japanese Accepted Name |
| OS | Official Synonym |
| PH | Pharmacopoeia Name |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
Further information on drug naming conventions: International Nonproprietary Names.
Important Notice: The Drugs.com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.
Further information
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