Rabies Immune Globulin, Human Dosage

Medically reviewed by Drugs.com. Last updated on Aug 16, 2023.

Usual Adult Dose for Rabies Prophylaxis

20 international units/kg, IM, once, as soon as possible after exposure, at the same time as the first dose of rabies vaccine

Comments:

• If anatomically feasible, thoroughly infiltrate the full dose in the area around and into the wounds, inject any remaining volume IM at a site distant from the vaccine administration site.
• Do not use in persons previously immunized with rabies vaccine regimen.
• Give as soon as possible after exposure, along with first dose of rabies vaccine.
• If treatment is delayed, still administer.
• If not given at same time vaccine was started, may be given up to and including day 7 of post-exposure prophylaxis series.
• Vaccination takes about 1 week for immunity; rabies immune globulin provides immediate passive immunization.
• Do not give more than the recommended dose - may suppress active antibody production.
• Consult local or state public health officials for questions about the need for treatment.

Usual Pediatric Dose for Rabies Prophylaxis

20 international units/kg, IM, once, as soon as possible after exposure, at the same time as the first dose of rabies vaccine

Comments:

• If anatomically feasible, thoroughly infiltrate the full dose in the area around and into the wounds, inject any remaining volume IM at a site distant from the vaccine administration site.
• Do not use in persons previously immunized with rabies vaccine regimen.
• Give as soon as possible after exposure, along with first dose of rabies vaccine.
• If treatment is delayed, still administer.
• If not given at same time vaccine was started, may be given up to and including day 7 of post-exposure prophylaxis series.
• Vaccination takes about 1 week for immunity; rabies immune globulin provides immediate passive immunization.
• Do not give more than the recommended dose - may suppress active antibody production.
• Consult local or state public health officials for questions about the need for treatment.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Other Comments

Administration advice:

• Never give in the same anatomical site as rabies vaccine.
• Preferred sites are the deltoid or lateral thigh.
• Do not administer in the gluteal region - may injure sciatic nerve.

Storage requirements:

• Refrigerate; do not freeze.

IV compatibility:

• Do not mix with rabies vaccine in the same syringe.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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