Actemra Alternatives Compared
| Actemra | Methotrexate | Hydroxychloroquine |
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| Actemra (tocilizumab) | Methotrexate | Hydroxychloroquine |
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Prescription only
Prescribed for Giant Cell Arteritis, Rheumatoid Arthritis, Cytokine Release Syndrome, COVID-19, Juvenile Idiopathic Arthritis, Polyarticular Juvenile Idiopathic Arthritis, Systemic... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Prescription only
Prescribed for Rheumatoid Arthritis, Lupus, Lyme Disease - Arthritis, Lichen Planopilaris, Dermatomyositis, Malaria, Malaria Prevention, Sjogren's Syndrome, Undifferentiated Connective Tissue... View more |
Related suggestions Popular comparisons
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| More about Actemra (tocilizumab) | More about Methotrexate | More about Hydroxychloroquine | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Actemra has an average rating of 6.9 out of 10 from a total of 46 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 21% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 334 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
Hydroxychloroquine has an average rating of 6.5 out of 10 from a total of 354 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 27% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See also: Actemra side effects in more detail. |
See also: Methotrexate side effects in more detail. |
See also: Hydroxychloroquine side effects in more detail. |
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| Generic Availability | ||||||||||||||||||||||||||
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N/A |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Actemra prices |
View all Methotrexate prices |
View all Hydroxychloroquine prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other tocilizumab brands include: Tofidence, Tyenne | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | Plaquenil, Sovuna | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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210 hours |
15 hours |
N/A |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category N
Not classified
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 412 drugs are known to interact with Actemra:
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A total of 706 drugs are known to interact with Methotrexate:
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A total of 470 drugs are known to interact with Hydroxychloroquine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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October 21, 2013 |
December 07, 1953 |
N/A |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.