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Zoloft User Reviews & Ratings (Page 4)

Zoloft has an average rating of 7.2 out of 10 from a total of 1,821 reviews on Drugs.com. 64% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Zoloft

  • Lou
  • Taken for less than 1 month
  • January 25, 2015

For Depression "It's my savior. I was in severe anxiety and depression for the last 6 months. It felt like there was no hope anymore. I started taking Zoloft, and today is my 4th week. It's not that I don't feel depressed anymore, I feel happy, enjoying every moment of life. I go to work full of motivation now. I feel like nothing can stress me out; I sound very confident in front of my colleagues. I am so thankful for this medicine. It gave me my potential, my efficiency, and my life back. No significant side effects, other than weight gain."

10 / 10
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285 Report
  • Happy...
  • August 18, 2019

For Social Anxiety Disorder "This Zoloft is life-changing stuff for my social anxiety. I tried the counseling, CBT, hypnosis, etc. I take these, and a week later, my critical anxious voice has disappeared. My social anxiety, which has ruined my life, gone from a 10 to a 2. Wow."

10 / 10
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172 Report
  • Kelly
  • Taken for 5 to 10 years
  • June 10, 2020

For Obsessive Compulsive Disorder "I have been taking 100mg Zoloft daily for almost 8 years, and I find it really helps with OCD, especially the dulling of intrusive thoughts that would normally cause me a lot of distress, anxiety and were quite frankly ruining my life. I am now at a stage where I am wondering whether I should attempt to wean myself off this drug, but am increasingly anxious about coming off the drug, as it has been so successful. I've had a few side effects, such as a reduced attention span and weight gain, but all in all, the drug has helped me live a normal life, with only two relapses in the eight years I've been on them. Both times I've relapsed, I have received help from a counsellor or CBT, but have stayed on the drug throughout, maintaining a steady dosage."

9 / 10
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148 Report

Frequently asked questions

  • 140756
  • December 25, 2014

For Depression "Zoloft has been a life saver for me. I honestly don't know how I would've gotten through the past year without it. I had anxiety and depression, but after I started taking Zoloft, I was finally starting to feel myself again and my headaches have gone away. If you have moderate to severe anxiety and depression, I would highly recommend this. It truly saved me."

10 / 10
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281 Report
  • Anony...
  • Taken for 1 to 6 months
  • January 18, 2022

For Panic Disorder "I promised myself that if this drug made my life better I would come back to comment on this thread. I'm a 21 year old male and started Zoloft about 3 months ago after being on Remeron for 4 years for GAD and Panic Disorder. I had no appetite, lost 20 pounds in about 2 weeks, throwing up twice a day, multiple panic attacks, and was in a dark place. My doctor suggested I try Zoloft to which I reluctantly agreed. I was titrated up to 150mg in about a week. My first week was awful. It peaked my anxiety, I felt extremely tense, racing thoughts, nausea, pacing around etc. 2nd week I felt extremely numb, emotionless, and just out of it. My least favorite side effect was brain fog. 8 weeks later and I felt amazing, I'm back to my old self but a lot more confident and happy. My advice is don't look at your progress day to day but rather week to week you'll see the improvement. I came on here everyday my first few weeks looking for hope that things would get better and now they are. :)"

10 / 10
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98 Report

Are you taking this medicine?

  • Krist...
  • Taken for 1 to 6 months
  • December 29, 2020

For Obsessive Compulsive Disorder "Suffering with existential OCD alongside with DP/DR episodes. I went to the psychiatrist and was prescribed Zoloft. In the 1st week, 25mg, in the 2nd week, 50mg, and in the 3rd week, 100mg until the end of month 1. The first 3 weeks were so awful, especially when I started with the 100mg tablets. I even had suicidal thoughts to the point where I couldn't even relate to anything. 4 days after the 100mg dose adjustments and everything is fine, more like a magic pill. This drug is awesome, but beware that you will feel way worse before you start to feel better! And every dose adjustment seems to reset the process."

9 / 10
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128 Report
  • Lisa
  • September 23, 2020

For Depression "Last February to April, I had a really bad bout with anxiety and depression. I tried Prozac and Cymbalta and had really bad side effects with both of them. I started 25mg of Zoloft in May 2020. About a month later, I went to 50mg and now am up to 75mg. I may even consider going to 100mg. The anxiety was better pretty quickly; the fatigue/depression took a bit longer, still some improvement needed, but so much better. I have also noticed that my PMS is barely noticeable. Very little to no agitation in the days before my period. My advice would be to increase slowly and allow time for improvement. It is gradual and can take months, but worth the wait."

10 / 10
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135 Report

More FAQ

  • Bette...
  • July 16, 2010

For Depression "I started taking 50mg generic sertraline about 2 weeks ago. I have had a very good experience with it and I love it. Thank God for this medicine and the improvements that it makes on the brain chemistry. Only experienced diarrhea for 1 day (which was okay for me because I've always struggled with constipation which only contributed to fatigue and depression). I'm more social (before I didn't care about doing much, even though I wanted to go out, when it came time to, I would end up going to bed), more easy going, less irritable and cranky. So much more patient with my kids. No side effects for me. Oh and I'm not eating ravenously at night because of stress and anxiety like I used to so it's helping me lose weight. Yay!"

10 / 10
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361 Report
  • scotty
  • Taken for less than 1 month
  • October 16, 2014

For Depression "I've been reading a lot of reviews on this site. Let me tell those who are new to this or thinking of going on sertraline. I have had horrible side effects with medication and got serotonin syndrome on citalopram. I was scared to death of going on sertraline. I'm on day 17 on 50mg, and I honestly say I've not had one single side effect at all. It's starting to hit me, and I feel amazing. One hundred times better than having anxiety. Wow."

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273 Report
  • Anxiety
  • October 4, 2019

For Panic Disorder "I never ever review anything but after being on this drug for now 4 weeks, I felt the need to review. I was previously on Zoloft (25mg) for 2 years before going off of it, and it was AMAZING. 6 months after stopping it, I could feel my anxiety slowly coming back and decided to go back on Zoloft (25mg). The first 3 weeks were horrible. I would wake up every morning with extreme anxiety, nausea/vomiting, and felt really out of it. For those 3 weeks, I had no energy or appetite (lost 10 lbs) which is hard when you need to work and go to school! I was living in a foggy state of 24/7 anxiety and felt like I couldn't escape from it. I knew it was the medicine making it worse, but I wanted to ride it out since I had positive experiences before. FINALLY after 4 weeks, I am starting to feel back to normal. I can get up in the morning without crippling anxiety and dread, attend school, and enjoy my relationship. Please give this medication AT LEAST 6-8 weeks to work. It eventually gets easier!"

9 / 10
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158 Report
  • vanch...
  • Taken for 1 to 6 months
  • July 18, 2019

For Major Depressive Disorder "I started having suicidal thoughts very suddenly and out of the blue, accompanied by unstoppable crying. When I saw my doctor, she asked about other symptoms like irritability, weight gain and difficulty meeting goals, doing the basics like keeping the house clean and personal care. All of these were issues for me, accruing over a year or longer. I didn't know I had depression, or that I'd had it before. Every crappy thing about my life was related to symptoms of depression. This medication Zoloft took about 8 weeks to work and has been life-changing. I've been happy, not cranky, I've started losing weight, tidying up, decorating my home, calling friends again. Thank you to the doctors and researchers responsible, the thoughts have stopped and life is better than ever before."

10 / 10
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162 Report
  • Cane
  • Taken for less than 1 month
  • June 7, 2020

For Social Anxiety Disorder "I don't see why some say: "I don't recommend this medication." Why dont you? Tell us plz: the dosage, other medications you are taking, age, etc. I am wanting to start zoloft but when I read these reviews I don't know what is better, having these panic attacks or trying zoloft. Every body is unique so it would be a great help if any one would give a better description of their situation. I thank all those who gave a great explanation of their situation."

10 / 10
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139 Report
  • Nikki...
  • Taken for 6 months to 1 year
  • December 28, 2019

For Post Traumatic Stress Disorder "After suffering years from watching my husband and son die next to me in a car wreck, I have finally, after 3 years, been able to date and move past my life-altering tragedy. Although Zoloft is not a cure-all, it blocks the horrible images, clears your mind, and gives you a positive boost. I'm not sure where I would be without it. 100mg a day has been most effective."

10 / 10
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150 Report
  • Sandr...
  • Taken for 1 to 6 months
  • December 16, 2022

For Major Depressive Disorder "5 years ago, I was a mess due to a bad breakup, drug & alcohol abuse & family issues. 8 months later stopped all substances & decided to go clean. That made me face reality, I suffered from PTSD, deep depression, severe anxiety & panic attacks & OCD, I was suicidal I couldn't stop over analyzing every single thought, my brain wouldn’t stop, and I had the craziest thoughts ever that I was so sure that I am going crazy. Finally, after 5 years I decided I need help. I tried many meds & NOTHING worked! I really believed that no med would do.Tried cepralex, seroquel, olizapen & others. Finally, Zoloft was the last solution, starting with 25 mg for 4 days then up to 50mg for 6 weeks. I noticed the change! Then on the 7th week, 75mg then finally 100mg. The side effects are horrible yes, increased anxiety and panic, loss of appetite and all, 6 weeks after increasing to 100 mg I swear I can jump and scream from happiness! & I am full of energy and hope! Plz give Zoloft time to work!"

10 / 10
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65 Report
  • piano
  • October 15, 2008

For Depression "I'm writing this post because I spent a lot of time researching online about Zoloft side effects before I finally decided to try it for my OCD/depression. I made a mental note to let other people considering this drug know what it was like after I tried it as well. I was worried that it might cause weight gain and that there may be sexual side effects. I was on this medication for 2 years and DID NOT experience weight gain or sexual side effects. The first few months I was on it, I had some stomach upset and trouble sleeping, but that disappeared shortly after. I have maintained a consistent body weight (within 5 lbs.) for years, and Zoloft did not seem to affect my weight at all. I lost a few pounds at first because of the stomach upset."

8 / 10
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380 Report
  • Renee
  • Taken for less than 1 month
  • April 2, 2022

For Panic Disorder "Hey everyone I’m a 32 year old female that started taking Zoloft a week ago! Your comments really helped me to even start taking it so thanks to everyone that left a review because I’m scared of medicine. I am to leave a review in hopes to help someone like me! I started on 25mg but broke it in half to get it into my system for one week and I will move up to my 25mg but my experience so far I have had sleepless nights, headaches, diarrhea, not really been hungry but y’all don’t let that scare you like it did me. I’m telling you even on a small dose I can tell a small adjustment already and I will be back in another week to update y’all on the dose increase, but take a leap of faith and try it I can already tell I’m feeling some what better just in a week! We are all in this together!"

8 / 10
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86 Report
  • MuchH...
  • Taken for 1 to 6 months
  • February 1, 2017

For Obsessive Compulsive Disorder "I started Zoloft because I was struggling with obsessive, repetitive thoughts about bad things happening to my children, which made me anxious all the time. The first 3 weeks were hell. Even the Klonopin the doctor gave me to get through it didn't help. It felt like my anxiety levels tripled. I could barely function. Between weeks 4-5, I transitioned to just feeling as anxious as I had been before. Then it felt like a balloon was inflating inside my head (in a good way), and the anxious thoughts were bouncing off the balloon instead of being allowed to collect and swirl around torturing me. Then I started having moments of feeling GOOD. And those moments grew into my new reality. My anxiety is 90% better. Zoloft gave me a new life."

10 / 10
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212 Report
  • Miracle...
  • Taken for 1 to 6 months
  • June 7, 2023

For Depression "Coming on here to share my positive experience to add to the other great reviews that I read religiously to get me through one of the hardest times of my life. 6 weeks ago, due to overcommitting and overwhelming myself for months, my depression and anxiety came back full force. I started having suicidal thoughts multiple times a day and couldn’t even go to work. I started on 50mg of Zoloft. I’ve been on Prozac and lexapro in the past and don’t remember either of them helping but this has been a GAME CHANGER. It took 6 weeks but I finally feel like the normal unanxious happy person I used to be so long ago. Do not give up on this medication!"

10 / 10
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47 Report
  • water...
  • Taken for 1 to 6 months
  • December 12, 2014

For Social Anxiety Disorder "Asking my doctor about Zoloft was one of the best decisions for me. I have suffered from anxiety as long as I can remember. I feel like a new person now. I didn't even fully realize how bad it was until taking Zoloft. I didn't want to take meds; I thought my anxiety was just part of who I was and something I would have to deal with forever. Zoloft has changed my life."

9 / 10
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253 Report
  • Rina
  • Taken for less than 1 month
  • August 9, 2020

For Obsessive Compulsive Disorder "I was suffering from depression my entire life, and I didn't even know it. I'm 32 years old and started taking Zoloft three weeks ago. At first, I suffered from many side effects: insomnia, dizziness, nausea, blurred vision, tired feeling, and even nervousness. It was the worst 10 days of my life. After enduring those 10 days, I was able to look at life differently. I'm able to accept flaws in anything, pardon excuses, laugh with my family and friends comfortably. I can see why people thought I was high maintenance. I was horrible to my family with unrealistic standards."

9 / 10
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  • Anonymous
  • May 9, 2009

For Depression "I was crying over the weirdest things and didn't want to get out of bed. Then I started taking Zoloft 50mg daily, a month ago. I felt relief an hour after taking it. The side effects for me were stomach upset, decrease in appetite, and sleepiness. That only lasted a week. After three weeks I increased the dose to 100mg which my doctor suggested in the beginning. I have been on many different antidepressants since I was a teenager and this is the first one that I feel 'normal' on. I don't feel emotionless or stay on a fake happiness high. I feel relieved and can deal with the day-to-day stresses."

10 / 10
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354 Report
  • zjohn...
  • December 26, 2019

For Social Anxiety Disorder "I started taking this for anxiety and have noticed a huge boost to my mood that I didn't expect. I went from feeling sad all the time to feeling amazing. Anxiety doesn't bother me and I feel happy for the first time in my life."

10 / 10
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141 Report
  • Silva...
  • May 26, 2015

For Depression "I was crippled with anxiety, depression, and nagging intrusive thoughts. Zoloft has allowed me to live again. Please don't allow the stigma and misinformation out there about antidepressants prevent you from getting help and finding relief. Once your body adjusts to Zoloft (this can take upwards of 2-4 weeks), you will find relief and peace. I used a pill cutter to cut the prescribed dose (25 mg) in half and took the half dose for two weeks. Then I increased it to the prescribed dose. This is much easier on the body. Please consider doing this so you're not overcome and discouraged by some of the initial side effects. Good luck, friends."

10 / 10
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238 Report
  • George
  • December 18, 2015

For Depression "I've been suffering with depression coupled with anxiety for over 10 years. It's been hell, ruining every aspect of my life (loss of relationships, my business, etc.). After seeing so many psychiatrists, I had lost hope and was getting very close to ending my life, so I tried to get help one more time. For the first time, I met a young doctor who listened. He prescribed me Zoloft 50mg. The change = I left my house within 2 weeks (major agoraphobia for 8 months), started talking to people, going out again with friends, preparing to launch my business again, and I feel happy. Not manic, HAPPY and measured. I'm praying that I stay this way. There is hope out there. Don't give up, guys. :)"

9 / 10
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227 Report
  • Severe...
  • Taken for 1 to 6 months
  • May 6, 2014

For Obsessive Compulsive Disorder "I have suffered with severe health anxiety and obsessive-compulsive disorder related to this anxiety for about 6 years. I would spend countless hours a day googling symptoms and doing certain health-related rituals, and it was taking over my life. I finally talked to my doctor at the urging of my family and ended up on 50 mg of Zoloft. I didn't want to take it because part of my health anxiety is a fear of any type of medication. After about 3 weeks of it sitting untouched in my cabinet, I started to take it. I didn't feel strange - no side effects. Maybe a little more sleepy at night? After about 3 weeks on Zoloft, I noticed that I didn't have the urge to Google health symptoms anymore, and I would forget to do some of my daily rituals."

9 / 10
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258 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.