SABCS: Outcomes No Worse for Survivors With Less Frequent Mammograms
By Elana Gotkine HealthDay Reporter
FRIDAY, Dec. 8, 2023 -- For women with breast cancer aged 50 years or older and three years postdiagnosis, outcomes are no worse with less frequent mammograms than annual mammograms, according to a study presented at the annual San Antonio Breast Cancer Symposium, held from Dec. 5 to 9 in San Antonio.
Janet A. Dunn, Ph.D., from the University of Warwick in the United Kingdom, and colleagues conducted a multicenter, randomized, controlled, phase III trial of annual mammography versus mammography every two years for conservation surgery and mammography every three years for mastectomy patients. The analyses included 5,235 women with breast cancer who were randomly assigned between April 2014 and September 2018; 87 percent had invasive disease.
The researchers found that 319 women died within a median follow-up of 5.4 years; 104 died from breast cancer (53 in annual arm; 51 in less frequent arm). At five years, breast cancer-specific survival was 98.2 and 98.3 percent in the annual and less frequent arms, respectively, for a hazard ratio of 1.04 (95 percent confidence interval, 0.71 to 1.54), demonstrating noninferiority of less frequent mammograms at the 3 and 1 percent margins. The five-year recurrence-free interval was 94.2 and 94.4 percent for the annual and less frequent arms, respectively (hazard ratio, 1.03; 95 percent confidence interval, 0.83 to 1.28), demonstrating noninferiority at the 2 percent margin. At five years, overall survival was 94.9 and 94.3 percent in the annual and less frequent arms, respectively (hazard ratio, 1.18; 95 percent confidence interval, 0.94 to 1.47), demonstrating noninferiority at the 3 percent margin.
"The trial demonstrated that the outcomes from undergoing less frequent mammograms were no worse than undergoing annual mammograms for this group of women," Dunn said in a statement.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted December 2023
Read this next
Pandemic Had Temporary Negative Effect on Breast Cancer Screening
THURSDAY, May 30, 2024 -- The COVID-19 pandemic had a transient negative effect on breast cancer screening overall and a prolonged negative effect on follow-up screening...
Patient Characteristics Linked to Performance of AI Algorithm for DBT
THURSDAY, May 30, 2024 -- For analyzing negative screening digital breast tomosynthesis (DBT) examinations, patient characteristics influence the case and risk scores of an...
Chemo + Breast Cancer Combo Accelerates Functional Decline in Seniors
WEDNESDAY, May 29, 2024 -- The combination of breast cancer and chemotherapy contributes to accelerated functional decline in older women with early-stage breast cancer, according...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.