Risk for Incident Dementia Increased With Diagnosed Depression
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
MONDAY, July 24, 2023 -- Men and women with diagnosed depression have an increased risk for dementia, according to a study published online July 24 in JAMA Neurology.
Holly Elser, M.D., Ph.D., from Aarhus University in Denmark, and colleagues examined the associations between early-, middle-, and late-life depression and incident dementia in a nationwide cohort study involving Danish individuals. Data were included from 246,499 individuals with diagnosed depression and 1,190,302 without depression.
The researchers found that 67.7 percent of those diagnosed with depression were diagnosed before the age of 60 years. Relative to the comparison cohort, those diagnosed with depression had a 2.41 times higher hazard of dementia. When the time elapsed from the index date was longer than 20 to 39 years (hazard ratio, 1.79) and among those diagnosed with depression in early, middle, or late life, the association persisted (hazard ratios, 3.08, 2.95, and 2.31 for 18 to 44 years, 45 to 59 years, and 60 years and older, respectively). Men had a greater hazard ratio for dementia than women (2.98 versus 2.21).
"Findings support our hypothesis that associations would persist regardless of time since depression diagnosis or the age at which depression was diagnosed," the authors write. "Our results therefore suggest that depression is not only an early symptom of dementia but also that depression is associated with an increase in dementia risk."
One author disclosed receiving fees from Peabody Arnold and having a patent for use of glecaprevir/pibrentasvir; a second author disclosed ties to Amgen.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted July 2023
Read this next
Teens May Experience Delays in Bipolar Progression After Major Depressive Disorder
FRIDAY, May 31, 2024 -- Adolescents may experience delayed bipolar disorder (BD) progression after major depressive disorder (MDD) diagnosis, according to a study published online...
Teen Smartphone Use Positively Tied to Mood
THURSDAY, May 30, 2024 -- Adolescent smartphone use is positively associated with mood, according to a study published online May 29 in PLOS ONE. Matt Minich, Ph.D., and...
Self-, Partner-Reported Cognitive Decline Linked to Tau
THURSDAY, May 30, 2024 -- Individuals who self-report and whose partners report cognitive decline have greater tau, which is driven by elevated beta-amyloid (Aβ), according...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.