Models Can Predict Breast Cancer-Related Lymphedema
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
FRIDAY, July 14, 2023 -- Preoperative and postoperative models are highly accurate for predicting breast cancer-related lymphedema (BCRL), according to a study published online July 12 in JAMA Surgery.
Danielle H. Rochlin, M.D., from Memorial Sloan Kettering Cancer Center in New York City, and colleagues conducted a prognostic study involving women with breast cancer who underwent axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB) from 1999 to 2020 to create a simple and accurate prediction model for BCRL. Data were included for 1,882 female patients (mean age, 55.6 years).
The researchers found that at a mean follow-up of 3.9 years, 11.6 percent of patients were diagnosed with BCRL. The BCRL rate was significantly higher among Black women compared with Asian, White, and other race women (22.1 percent versus 12.5, 10.1, and 14.8 percent, respectively). Accuracy for model 1 (preoperative), which included age, weight, height, race, ALND/SLNB status, any radiation therapy, and any chemotherapy, was 73.0 percent, sensitivity was 76.6 percent, specificity was 72.5 percent, and the area under the receiver operating characteristic curve (AUC) was 0.78 at a cutoff of 0.18. For model 2 (postoperative), which included age, weight, race, ALND/SLNB status, any chemotherapy, and patient-reported arm swelling, accuracy was 81.1 percent, sensitivity was 78.0 percent, specificity was 81.5 percent, and the AUC was 0.86 at a cutoff of 0.10. Higher AUCs were seen for both models on external or internal validation.
"By implementing these predictive models in a patient-facing format within clinical care, our goal is to direct patients to appropriate preoperative and postoperative interventions in a manner that balances precision and practicality," the authors write.
Two authors disclosed ties to the biopharmaceutical, medical device, and publishing industries.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted July 2023
Read this next
Resistance Exercise Boosts Outcomes After Early-Stage Breast Cancer Surgery
FRIDAY, June 7, 2024 -- Early resistance exercise following surgery for early-stage breast cancer improves shoulder range of motion (ROM) and strength at one month and six months...
ASCO: Neoadjuvant Ipilimumab + Nivolumab Ups Survival in Resectable Melanoma
WEDNESDAY, June 5, 2024 -- Neoadjuvant ipilimumab plus nivolumab followed by surgery results in longer event-free survival than surgery followed by adjuvant nivolumab among...
Odds of Death Lower With Surgery for Hip Fracture in Patients With Dementia
MONDAY, June 3, 2024 -- For community-dwelling patients with dementia and fracture of the femoral head and neck, the odds of death are lower for those treated surgically...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.