In-Hospital Mortality Evaluated for SARS-CoV-2-Linked Sepsis
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
WEDNESDAY, Oct. 4, 2023 -- From March 2020 to November 2022, there was a decline in crude in-hospital mortality for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated sepsis, according to a study published online Sept. 29 in JAMA Network Open.
Claire N. Shappell, M.D., M.P.H., from Harvard Medical School/Harvard Pilgrim Health Care Institute in Boston, and colleagues conducted a retrospective cohort study of adults hospitalized at five Massachusetts hospitals between March 2020 and November 2022 to describe trends in the quarterly incidence and in-hospital mortality for SARS-CoV-2-associated and presumed bacterial sepsis.
Data were included for 431,017 hospital encounters from 261,595 individuals. Of these, 5.4 percent were from SARS-CoV-2, 1.5 percent had SARS-CoV-2-associated sepsis, and 7.1 percent had presumed bacterial sepsis without SARS-CoV-2 infection. The researchers found a decline in the crude in-hospital mortality for SARS-CoV-2-associated sepsis from 33.4 to 14.9 percent in the first and last quarter (adjusted odds ratio, 0.88 per quarter). For presumed bacterial sepsis, crude mortality was 14.5 percent and was stable across quarters. Electronic health record (EHR)-based SARS-CoV-2-associated sepsis criteria performed well relative to sepsis-3 criteria on medical record reviews of 200 SARS-CoV-2-positive hospitalizations (sensitivity, 90.6 percent; specificity, 91.2 percent).
"These findings highlight the high burden of SARS-CoV-2-associated sepsis and demonstrate the feasibility of using EHR-based algorithms to conduct surveillance for viral sepsis," the authors write.
One author disclosed ties to UpToDate and Cytovale.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted October 2023
Further Support and Information on COVID-19
Read this next
Considerable Variation Seen in Mortality Rates for Suspected Sepsis
TUESDAY, May 28, 2024 -- There is considerable variation in mortality rates among patients with suspected sepsis, according to a research letter published online May 28 in the...
Mortality Higher for COVID-19 Hospitalization Than for Flu in 2023/2024 Season
WEDNESDAY, May 22, 2024 -- In fall/winter 2023/2024, the risk for death in patients hospitalized for COVID-19 was greater than the risk for death in patients hospitalized for...
Global Life Expectancy, Disease Burden Set to Keep Improving
WEDNESDAY, May 22, 2024 -- Life expectancy and age-standardized disease burden are expected to continue improving between 2022 and 2050, according to the Global Burden of Disease...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.