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Lisdexamfetamine (Monograph)

Brand name: Vyvanse
Drug class: Amphetamines
VA class: CN801
Chemical name: (2S)-2,6-diamino-N-[(1S)-1-methyl-2-phenylethly] hexanamide dimethanesulfonate
Molecular formula: C15H25N3O • (CH4O3S)2
CAS number: 608137-33-3

Medically reviewed by Drugs.com on May 18, 2023. Written by ASHP.

Warning

FDA drug safety communication (5/11/2023):

To address continuing concerns of misuse, abuse, addiction, and overdose of prescription stimulants, FDA is requiring updates to the Boxed Warning and other information to ensure the prescribing information is consistent across the entire class of these drugs.500

The current prescribing information in some prescription stimulants does not provide up to date warnings about the harms of misuse and abuse, particularly when these drugs are shared with individuals for whom they are not prescribed. 500 An FDA review found that most individuals who misuse prescription stimulants obtain their drugs from family members or peers, and that such sharing of prescription stimulants was a major contributor to nonmedical use and addiction.500

Updates will include information that patients should never share their prescription stimulants with anyone, and the Boxed Warning information will describe the risks of misuse, abuse, addiction, and overdose consistently across all medicines in the class.500 The Boxed Warning will also advise healthcare professionals to monitor patients closely for signs and symptoms of misuse, abuse, and addiction.500

Warning

    Abuse Potential
  • CNS stimulants (e.g., amphetamines, methylphenidate) have a high potential for abuse and dependence.1 48

  • Assess risk of abuse prior to initiation of lisdexamfetamine and monitor patients for signs of abuse and dependence during therapy.48

Introduction

Prodrug of dextroamphetamine; noncatechol, sympathomimetic amine with CNS-stimulating activity.1 8 28

Uses for Lisdexamfetamine

Attention-Deficit/Hyperactivity Disorder

Used as adjunct to psychological, educational, social, and other remedial measures in the treatment of attention-deficit/hyperactivity disorder (ADHD) (hyperkinetic disorder, hyperkinetic syndrome of childhood, minimal brain dysfunction).1 3 6 7 8 28

Safety and efficacy established in children ≥6 years of age, adolescents, and adults who met criteria for ADHD.2 3 4 29 30 44 45 46 48

Almost all studies comparing behavioral therapy versus stimulants alone show a much stronger therapeutic effect from stimulants than from behavioral therapy, and stimulants (e.g., amphetamines, methylphenidate) remain the drugs of choice for the management of ADHD.5 6 7 10 11 12 13 14 15 16 17 18 19 20

Drug therapy not indicated in all patients with ADHD; consider such therapy only after performing a complete evaluation including medical history.6 17 18

Base use on age, adequate diagnosis (based on medical, special psychological, educational, social resources), and the clinician’s assessment of the severity, duration, and frequency of symptoms and not solely on one or more behavioral characteristics.5 6 17

Binge-Eating Disorder

Used for treatment of moderate to severe binge-eating disorder in adults.40 48 Reduces mean number of binge days per week compared with placebo.40 48

Do not use for weight loss; use of other sympathomimetic drugs for weight loss associated with serious adverse cardiovascular events.48 Efficacy and safety of lisdexamfetamine for treatment of obesity not established.48

Lisdexamfetamine Dosage and Administration

General

Administration

Oral Administration

Administer capsules or chewable tablets once daily in the morning without regard to meals.1 48 Because of potential for insomnia, avoid administering in the afternoon.1 28 30

Swallow capsules whole.1 48

Alternatively, capsule may be opened and entire contents mixed with water, orange juice, or yogurt until completely dispersed; administer resulting mixture immediately.1 48 Do not store mixture for use at later time.1 48

Do not subdivide capsule contents; do not administer a dose less than the entire contents of one capsule or one chewable tablet.1 48

Chew tablets thoroughly before swallowing.48

Capsules can be substituted for chewable tablets on a mg-per-mg basis.48

Dosage

Available as lisdexamfetamine dimesylate; dosage expressed in terms of the salt.1

Pediatric Patients

Attention-Deficit/Hyperactivity Disorder
Oral

Children and adolescents ≥6 years of age: Initially, 30 mg once daily; dosage may be adjusted in 10- or 20-mg increments at weekly intervals.1 28 30 48

If the initial 30-mg daily dosage is not tolerated, dosage may be decreased to 20 mg daily.27

Adults

Attention-Deficit/Hyperactivity Disorder
Oral

Initially, 30 mg once daily; dosage may be adjusted in 10- or 20-mg increments at weekly intervals.1 28 48

If the initial 30-mg daily dosage is not tolerated, dosage may be decreased to 20 mg daily.27

Binge-Eating Disorder
Oral

Initially, 30 mg once daily; adjust dosage in 20-mg increments at weekly intervals to target dosage of 50–70 mg daily.48

Discontinue drug if binge eating does not improve.48

Prescribing Limits

Pediatric Patients

Attention-Deficit/Hyperactivity Disorder
Oral

Maximum 70 mg daily.1

Adults

Attention-Deficit/Hyperactivity Disorder
Oral

Maximum 70 mg daily.1

Binge-Eating Disorder
Oral

Maximum 70 mg daily.48

Special Populations

Renal Impairment

Severe renal impairment (GFR 15 to <30 mL/minute per 1.73 m2): Maximum 50 mg daily.48

End-stage renal disease (ESRD) (GFR <15 mL/minute per 1.73 m2): Maximum 30 mg daily.48

Cautions for Lisdexamfetamine

Contraindications

Warnings/Precautions

Warnings

Abuse Potential

Potential for abuse and dependence.48 Assess risk of abuse prior to initiation of lisdexamfetamine and monitor patients for signs of abuse and dependence during therapy.48 (See Boxed Warning.)

Consider the possibility that family members may abuse the patient’s medication.5

Other Warnings and Precautions

Sudden Death and Serious Cardiovascular Events

Sudden unexplained death, stroke, and MI reported in adults with ADHD receiving usual dosages of stimulants; sudden death also reported in children and adolescents with structural cardiac abnormalities or other serious cardiac conditions receiving usual dosages of the drugs.1 9 Postmarketing experience with lisdexamfetamine includes reports of cardiomyopathy, chest pain.48

Although an initial epidemiologic study showed association between use of stimulants and sudden unexplained death in healthy children and adolescents,31 32 33 subsequent large epidemiologic studies in children and young adults or in adults 25–64 years of age found no association between ADHD drug use (stimulants, atomoxetine, pemoline [no longer commercially available in US]) and serious cardiovascular events (MI, stroke, sudden cardiac death), although small increases in cardiovascular risk could not be excluded.35 36 37 38

Thoroughly review medical history (including evaluation for family history of sudden death or ventricular arrhythmia) and perform physical examination in all children, adolescents, and adults being considered for stimulant therapy; if initial findings suggest presence of cardiac disease, perform further cardiac evaluation (e.g., ECG, echocardiogram).1 5 6

Avoid use of CNS stimulants in patients with known serious structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, CAD, or other serious cardiac conditions.1 6 8 9 48

Patients who develop exertional chest pain, unexplained syncope, arrhythmias, or other manifestations suggestive of cardiac disease during stimulant therapy should undergo prompt cardiac evaluation.1 28 48

Effects on BP and Heart Rate

Possible modest increases in average BP (i.e., by about 2–4 mm Hg) and heart rate (i.e., by about 3–6 bpm); larger increases may occur.1 28 Monitor all patients for changes in BP and heart rate.1 48

Exacerbation or Precipitation of Psychotic Symptoms

May exacerbate symptoms of behavior disturbance and thought disorder in patients with preexisting psychotic disorder.1 5

Psychotic symptoms (e.g., hallucinations, delusional thinking) may occur with usual dosages in children and adolescents without prior history of psychotic illness.1 6 If psychotic symptoms occur, consider causal relationship to stimulants, and discontinue therapy as appropriate.1 6

Precipitation of Manic Symptoms

May precipitate mixed or manic episodes in patients with bipolar disorder.1 48 Prior to initiating therapy, carefully screen patients for risk factors for developing a manic episode; with screening, include a detailed psychiatric history (e.g., comorbid depressive symptoms or history of depressive symptoms; family history of suicide, bipolar disorder, or depression).1 48

Manic symptoms may occur with usual dosages in children and adolescents without prior history of mania.1 If manic symptoms occur, consider causal relationship to stimulants, and discontinue therapy as appropriate.1

Other Nervous System Effects

Amphetamines may impair the ability to engage in potentially hazardous activities (e.g., operating machinery or vehicles).1 Postmarketing experience includes reports of dyskinesia, tics, depression, dermatillomania, aggression, seizures.48

Growth Suppression

Long-term (i.e., >12 months) administration expected to cause at least a temporary suppression of normal weight and/or height patterns in some children and adolescents.1 6 Dose-related weight loss reported in children and adolescents during 4 weeks of therapy with lisdexamfetamine.1 48

Manufacturer recommends monitoring growth during treatment; patients not growing or gaining weight as expected may require temporary discontinuance of treatment.1 6 28 48 However, AAP states that studies of stimulants in children found little or no decrease in expected height, with any decrease in growth early in treatment being compensated for later on.7

Peripheral Vascular Effects

Peripheral vascular disorders (e.g., Raynaud's phenomenon) reported in patients in all age groups receiving stimulants at therapeutic dosages and at various times throughout treatment course.48 Manifestations usually intermittent and mild, but ulceration of digits and/or breakdown of soft tissue occur rarely.48 Carefully observe patients for digital changes.48 (See Advice to Patients.)

Improvement generally observed following dosage reduction or drug discontinuance; some patients may require further evaluation (e.g., referral to rheumatologist).48

Serotonin Syndrome

Potentially life-threatening serotonin syndrome may occur when amphetamines are used concomitantly with other drugs that affect serotonergic neurotransmission (e.g., MAO inhibitors, SSRIs, SNRIs, tricyclic antidepressants, 5-hydroxytryptamine [5-HT] type 1 receptor agonists [“triptans”], buspirone, fentanyl, lithium, tramadol, tryptophan, St. John's wort [Hypericum perforatum]).48 May also occur when lisdexamfetamine and CYP2D6 inhibitors are used concomitantly.48 (See Interactions.)

Symptoms may include mental status changes (e.g., agitation, hallucinations, delirium, coma), autonomic instability (e.g., tachycardia, labile BP, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular aberrations (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, GI symptoms (e.g., nausea, vomiting, diarrhea).48

Concomitant use of lisdexamfetamine and MAO inhibitors is contraindicated.48 (See Contraindications under Cautions.)

If concomitant therapy with other serotonergic drugs or CYP2D6 inhibitors is clinically warranted, consider lower initial lisdexamfetamine dosage and monitor patient for emergence of serotonin syndrome, particularly during initiation of therapy and dosage increases.48 (See Advice to Patients.)

If symptoms of serotonin syndrome occur, discontinue lisdexamfetamine and any other concomitant serotonergic agents immediately and initiate supportive therapy.48

Visual Effects

Visual disturbances reported with stimulants.48 Postmarketing experience includes reports of mydriasis, diplopia, difficulty with accommodation, blurred vision.48

Hepatic Effects

Postmarketing experience includes reports of eosinophilic hepatitis.48 49

GI Effects

Postmarketing experience includes reports of dysgeusia, bruxism, constipation.48

Musculoskeletal Effects

Postmarketing experience includes reports of rhabdomyolysis.48

Alopecia

Postmarketing experience includes reports of alopecia.48

Endocrine Effects

Postmarketing experience includes reports of changes in libido, frequent or prolonged erections.48

Specific Populations

Pregnancy

May cause fetal harm.25 48 Only limited data available in pregnant women.48 Amphetamines may stimulate uterine contractions in pregnant women increasing risk of premature delivery.48 Risk of prematurity and low birth weight in infants born to amphetamine-dependent women; monitor such infants for withdrawal symptoms (e.g., feeding difficulties, irritability, agitation, excessive drowsiness).25 48

In animals, no effects on embryofetal morphology or survival when lisdexamfetamine administered throughout organogenesis.48 Prenatal and postnatal studies not conducted specifically with lisdexamfetamine.48 Administration of amphetamine to pregnant rats during gestation and lactation resulted in decreased pup survival and body weight correlating with developmental delays at clinically relevant dosages of amphetamine.48

Lactation

Distributed into milk.25 48 No reports of adverse effects on nursing infants.25 48 Large dosages of dextroamphetamine may interfere with milk production, especially in women whose lactation is not well established.48 Because of potential for serious adverse effects to lisdexamfetamine in nursing infants, breast-feeding not recommended during therapy.48

Pediatric Use

ADHD: Safety and efficacy not established in children <6 years of age.48

Binge-eating disorder: Safety and efficacy not established in pediatric patients <18 years of age.48

Psychotic (e.g., hallucinations, delusional thinking) or manic symptoms reported in children and adolescents receiving stimulants for management of ADHD.1 48 (See Warnings under Cautions.)

Sudden death reported in children and adolescents with structural cardiac abnormalities or other serious cardiac conditions receiving usual dosages of stimulants.1 48

Long-term administration expected to cause at least a temporary suppression of normal weight and/or height patterns in some children and adolescents.1 (See Growth Suppression under Cautions.)

Geriatric Use

Insufficient experience in patients ≥65 years of age to determine whether they respond differently than younger adults.48 Differences not identified with other reported clinical experience in responses between geriatric and younger adults.48

Hepatic Impairment

Not specifically studied in hepatic impairment.27

Renal Impairment

Reduced clearance and increased exposure of dextroamphetamine observed in patients with severe renal impairment or ESRD.48

Dosage adjustment recommended in severe renal impairment or ESRD.48 (See Renal Impairment under Dosage and Administration.)

Dialysis does not substantially affect clearance of dextroamphetamine.48

Common Adverse Effects

Children, adolescents, or adults with ADHD: Anorexia, anxiety, decreased appetite, decreased weight, diarrhea, dizziness, dry mouth, irritability, insomnia, nausea, upper abdominal pain, vomiting.48

Adults with binge-eating disorder: Dry mouth, insomnia, decreased appetite, increased heart rate, constipation, jittery feeling, anxiety.48

Drug Interactions

Amphetamines and their derivatives are metabolized by CYP2D6 and may show mild inhibition of CYP2D6 metabolism.48 The prodrug lisdexamfetamine not metabolized by CYP isoenzymes before its conversion to dextroamphetamine.48

No clinically important interactions shown with lisdexamfetamine and substrates of CYP1A2, 2D6, or 3A; potential for minimal inhibition of CYP2C19.41 Dosage adjustment of concomitantly administered substrates of these isoenzymes not necessary.48

Drugs Affecting Hepatic Microsomal Enzymes

CYP2D6 inhibitors: Potential pharmacokinetic interaction (increased exposure to dextroamphetamine); may increase risk of serotonin syndrome.48 Consider alternative therapy with a non-serotonergic drug or drug that does not inhibit CYP2D6.48

Use concomitantly only when potential benefit justifies the potential risk.48 If clinically warranted, use lower dosages of lisdexamfetamine during initiation of therapy.48 Monitor patients for signs and symptoms of serotonin syndrome, especially when therapy is initiated or dosage increased.48

If serotonin syndrome occurs, discontinue lisdexamfetamine, the CYP2D6 inhibitor, and any concomitantly administered serotonergic agents.48 (See Specific Drugs, Tests, and Foods under Interactions and also see Serotonin Syndrome under Cautions.)

Serotonergic Drugs

Potential pharmacologic interaction (potentially life-threatening serotonin syndrome) with serotonergic drugs.48

Use concomitantly only when potential benefit justifies the potential risk.48 If clinically warranted, use lower dosages of lisdexamfetamine during initiation of therapy.48 Monitor patients for signs and symptoms of serotonin syndrome, especially when therapy is initiated or dosage increased.48

If serotonin syndrome occurs, discontinue lisdexamfetamine and the concomitant serotonergic drug(s).48 (See Specific Drugs, Tests, and Foods under Interactions and also see Serotonin Syndrome under Cautions.)

Specific Drugs, Tests, and Foods

Drug, Test, or Food

Interaction

Comments

Acidifying agents, urinary (ammonium chloride, ascorbic acid, methenamine salts, sodium acid phosphate, cranberry juice)

Increased urinary excretion and decreased serum concentrations and efficacy of amphetamines1 8 48

Increase lisdexamfetamine dosage based on clinical response48

Alkalinizing agents, urinary (carbonic anhydrase inhibitors, sodium bicarbonate, some thiazides)

Decreased urinary excretion and increased serum concentrations of amphetamines1 8 48

Avoid concomitant use48

Antidepressants, SSRIs or SNRIs (e.g., fluoxetine, paroxetine)

Risk of potentially life-threatening serotonin syndrome48

Fluoxetine, paroxetine: Possible increased dextroamphetamine exposure48

Use concomitantly only if potential benefit justifies potential risk48

If concomitant therapy is clinically warranted, consider lower initial lisdexamfetamine dosage and carefully observe patient, particularly during drug initiation or dosage titration48

If serotonin syndrome occurs, immediately discontinue lisdexamfetamine, the antidepressant, and any concomitantly administered serotonergic agents; initiate supportive and symptomatic therapy48

Antidepressants, tricyclic (e.g., desipramine, protriptyline)

Risk of potentially life-threatening serotonin syndrome48

Enhanced activity of tricyclic antidepressants; desipramine or protriptyline may cause striking and sustained increases in dextroamphetamine concentrations in the brain; cardiovascular effects can be potentiated48

Use concomitantly only if potential benefit justifies potential risk48

If concomitant therapy is clinically warranted, consider lower initial lisdexamfetamine dosage and carefully observe patient, particularly during drug initiation or dosage titration48

If serotonin syndrome occurs, immediately discontinue lisdexamfetamine, the antidepressant, and any concomitantly administered serotonergic agents; initiate supportive and symptomatic therapy48

Monitor patients frequently; adjust dosage or use alternative therapy based on clinical response48

Buspirone

Risk of potentially life-threatening serotonin syndrome48

Use concomitantly only if potential benefit justifies potential risk48

If concomitant therapy is clinically warranted, consider lower initial lisdexamfetamine dosage and carefully observe patient, particularly during drug initiation or dosage titration48

If serotonin syndrome occurs, immediately discontinue lisdexamfetamine, buspirone, and any concomitantly administered serotonergic agents; initiate supportive and symptomatic therapy48

Fentanyl

Risk of potentially life-threatening serotonin syndrome48

Use concomitantly only if potential benefit justifies potential risk48

If concomitant therapy is clinically warranted, consider lower initial lisdexamfetamine dosage and carefully observe patient, particularly during drug initiation or dosage titration48

If serotonin syndrome occurs, immediately discontinue lisdexamfetamine, fentanyl, and any concomitantly administered serotonergic agents; initiate supportive and symptomatic therapy48

Guanfacine

No clinically important pharmacokinetic interaction43

No dosage adjustment necessary48

5-HT1 receptor agonists (“triptans”)

Risk of potentially life-threatening serotonin syndrome48

Use concomitantly only if potential benefit justifies potential risk48

If concomitant therapy is clinically warranted, consider lower initial lisdexamfetamine dosage and carefully observe patient, particularly during drug initiation or dosage titration48

If serotonin syndrome occurs, immediately discontinue lisdexamfetamine, the triptan, and any concomitantly administered serotonergic agents; initiate supportive and symptomatic therapy48

Lithium

Risk of potentially life-threatening serotonin syndrome48

Use concomitantly only if potential benefit justifies potential risk48

If concomitant therapy is clinically warranted, consider lower initial lisdexamfetamine dosage and carefully observe patient, particularly during drug initiation or dosage titration48

If serotonin syndrome occurs, immediately discontinue lisdexamfetamine, lithium, and any concomitantly administered serotonergic agents; initiate supportive and symptomatic therapy48

MAO inhibitors (e.g., isocarboxazid, linezolid, methylene blue, phenelzine, selegiline, tranylcypromine)

Potentially life-threatening hypertensive crisis or serotonin syndrome1 48

MAO inhibitors slow amphetamine metabolism, increasing their effect on release of norepinephrine and other monoamines leading to headaches and other signs of hypertensive crisis48

Amphetamines contraindicated in patients currently or recently (within 14 days) receiving MAO inhibitor1 48

Omeprazole

No clinically important pharmacokinetic interaction41 48

No dosage adjustment necessary48

Quinidine

Risk of potentially life-threatening serotonin syndrome48

Use concomitantly only if potential benefit justifies potential risk48

If concomitant therapy is clinically warranted, consider lower initial lisdexamfetamine dosage and carefully observe patient, particularly during drug initiation or dosage titration48

If serotonin syndrome occurs, immediately discontinue lisdexamfetamine, quinidine, and any concomitantly administered serotonergic agents; initiate supportive and symptomatic therapy48

Ritonavir

Risk of potentially life-threatening serotonin syndrome48

Use concomitantly only if potential benefit justifies potential risk48

If concomitant therapy is clinically warranted, consider lower initial lisdexamfetamine dosage and carefully observe patient, particularly during drug initiation or dosage titration48

If serotonin syndrome occurs, immediately discontinue lisdexamfetamine, ritonavir, and any concomitantly administered serotonergic agents; initiate supportive and symptomatic therapy48

St. John’s wort (Hypericum perforatum)

Risk of potentially life-threatening serotonin syndrome48

Use concomitantly only if potential benefit justifies potential risk48

If concomitant therapy is clinically warranted, consider lower initial lisdexamfetamine dosage and carefully observe patient, particularly during drug initiation or dosage titration48

If serotonin syndrome occurs, immediately discontinue lisdexamfetamine, St. John's wort, and any concomitantly administered serotonergic agents; initiate supportive and symptomatic therapy48

Tramadol

Risk of potentially life-threatening serotonin syndrome48

Use concomitantly only if potential benefit justifies potential risk48

If concomitant therapy is clinically warranted, consider lower initial lisdexamfetamine dosage and carefully observe patient, particularly during drug initiation or dosage titration48

If serotonin syndrome occurs, immediately discontinue lisdexamfetamine, tramadol, and any concomitantly administered serotonergic agents; initiate supportive and symptomatic therapy48

Tryptophan

Risk of potentially life-threatening serotonin syndrome48

Use concomitantly only if potential benefit justifies potential risk48

If concomitant therapy is clinically warranted, consider lower initial lisdexamfetamine dosage and carefully observe patient, particularly during drug initiation or dosage titration48

If serotonin syndrome occurs, immediately discontinue lisdexamfetamine, tryptophan, and any concomitantly administered serotonergic agents; initiate supportive and symptomatic therapy48

Venlafaxine

Additive effects on BP and heart rate reported42

No clinically important pharmacokinetic interaction48

No dosage adjustment necessary; monitor BP and heart rate42 48

Lisdexamfetamine Pharmacokinetics

Absorption

Bioavailability

Lisdexamfetamine (a prodrug of dextroamphetamine) is rapidly absorbed from the GI tract.1 28 Peak plasma concentrations of lisdexamfetamine occur in approximately 1 hour; concentrations are low and transient; nonquantifiable by 8 hours after administration.1 Peak plasma concentrations of dextroamphetamine occur in approximately 3.5–3.7 hours.1 3 30

Onset

Occurs within 2 hours after oral administration.3

Duration

Approximately 10–12 hours.1 8 27

Food

Food (high-fat meal or yogurt) delays time to peak plasma concentration of dextroamphetamine by about 1 hour, but administration with high-fat meal, yogurt, or orange juice does not affect magnitude of peak plasma concentration or AUC of dextroamphetamine.1 48

Distribution

Extent

Amphetamines readily cross the blood-brain barrier and are distributed into most body tissues.26

Amphetamines are distributed into milk in concentrations 3–7 times maternal blood concentrations.21 25

Elimination

Metabolism

Lisdexamfetamine (a prodrug of dextroamphetamine) is converted to l-lysine and dextroamphetamine mainly via hydrolytic activity of RBCs, which have high capacity for this metabolism.1 48

Lisdexamfetamine is not metabolized by CYP isoenzymes.1

Elimination Route

Excreted principally in urine.1 Approximately 96% of a 70-mg radiolabeled oral dose of lisdexamfetamine was recovered in urine; parent drug accounted for about 2% of the recovered radioactivity.1

Changes in urinary pH may alter excretion of amphetamines.1 (See Specific Drugs, Tests, and Foods under Interactions.)

Half-life

Lisdexamfetamine: <1 hour;1 8 dextroamphetamine: 9.4–13 hours.3 8 30

Stability

Storage

Oral

Capsules, Chewable Tablets

Tight, light-resistant containers at 20–25°C (may be exposed to 15–30°C).1 48

Actions

Advice to Patients

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Subject to control under the Federal Controlled Substances Act of 1970 as a schedule II (C-II) drug.1

Lisdexamfetamine Dimesylate

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Capsules

10 mg

Vyvanse (C-II)

Shire

20 mg

Vyvanse (C-II)

Shire

30 mg

Vyvanse (C-II)

Shire

40 mg

Vyvanse (C-II)

Shire

50 mg

Vyvanse (C-II)

Shire

60 mg

Vyvanse (C-II)

Shire

70 mg

Vyvanse (C-II)

Shire

Tablets, chewable

10 mg

Vyvanse (C-II)

Shire

20 mg

Vyvanse (C-II)

Shire

30 mg

Vyvanse (C-II)

Shire

40 mg

Vyvanse (C-II)

Shire

50 mg

Vyvanse (C-II)

Shire

60 mg

Vyvanse (C-II)

Shire

AHFS DI Essentials™. © Copyright 2024, Selected Revisions May 18, 2023. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

References

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