Poliovirus Vaccine Inactivated Shortage

• • Sanofi Pasteur had IPOL vaccine on allocation due to the shortage of other combination vaccines (e.g., Pentacel).[1,2]

• • IPOL, Sanofi Pasteur, 5 mL multiple dose vial, 1 count, NDC 49281-0860-10

Estimated Resupply Dates

• • Sanofi Pasteur has IPOL vaccine available.[1]

Implications for Patient Care

• • IPOL is labeled for primary immunization against infection with poliovirus Types 1, 2, and 3 in persons ages 6 weeks and older.[3]

Safety

• • Ensure patients receive the adequate number of vaccinations as outlined by the Centers for Disease Control and Prevention (CDC) Recommended Immunization Schedules.[4,5]

Alternative Agents & Management

• • The CDC has a guidance document available for clinicians during the shortage of the Pentacel vaccine and the implications with other vaccines like inactivated poliovirus vaccine. Available at: http://www.cdc.gov/vaccines/vac-gen/shortages/downloads/pentacel-delay.pdf.[6]

References

• 1. Sanofi Pasteur (personal communications). February 1 and 10, March 22, April 26, June 16, August 10, October 11, December 5, 2016; and January 9, 2017.
  2. Sanofi Pasteur. Dear Health Care Provider Letter (December 2015). Available at: https://www.vaccineshoppe.com/mailing/VSH/2015/12allo30341/index.html. Accessed February 10, 2016.
  3. Sanofi Pasteur. IPOL Poliovirus Vaccine Inactivated [product labeling]. Swiftwater, PA: Sanofi Pasteur; 2015.
  4. Centers for Disease Control and Prevention (CDC). General Recommendations on Immunization, Recommendations of the Advisory Committee on Immunization Practice. MMWR Morb Mortal Wkly Rep. 2011 Jan 28;60(RR02):1-60. Available online at: http://www.cdc.gov/mmwr/pdf/rr/rr6002.pdf. Accessed January 14, 2016.
  5. Department of Health and Human Services, Centers for Disease Control and Prevention. Recommended Immunization Schedule for Persons Ages 0 to 18 Years, United States 2015. Available at: http://www.cdc.gov/vaccines/schedules/downloads/child/0-18yrs-child-combined-schedule.pdf. Accessed January 14, 2016.
  6. Department of Health and Human Services, Centers for Disease Control and Prevention. Guidance for vaccinating children during the 2015-16 Pentacel manufacturing delay. Available at http://www.cdc.gov/vaccines/vac-gen/shortages/downloads/pentacel-delay.pdf. Accessed January 14, 2016.