Fentanyl Citrate Injection Shortage

• • Fentanyl citrate solution for injection, Hikma, 50 mcg/mL, 0.5 mL syringe, 10 count, NDC 00641-6249-10
  • Fentanyl citrate solution for injection, Hikma, 50 mcg/mL, 1 mL syringe, 10 count, NDC 00641-6248-10
  • Fentanyl citrate solution for injection, Hikma, 50 mcg/mL, 5 mL vial, 25 count, NDC 00641-6028-25

• • Akorn ceased operations in February 2023.
  • Fresenius Kabi has fentanyl on shortage due to manufacturing delays.
  • Hikma has fentanyl injection on shortage due to supply and demand issues. They are not currently marketing fentanyl ampules, just vials.
  • Pfizer has fentanyl injection available.

• • Fentanyl citrate solution for injection, Fresenius Kabi, 50 mcg/mL, 1 mL syringe, 10 count, NDC 63323-0808-11
  • Fentanyl citrate solution for injection, Fresenius Kabi, 50 mcg/mL, 1 mL vial, 25 count, NDC 63323-0806-01
  • Fentanyl citrate solution for injection, Fresenius Kabi, 50 mcg/mL, 2 mL vial, 25 count, NDC 63323-0806-02
  • Fentanyl citrate solution for injection, Fresenius Kabi, 50 mcg/mL, 20 mL vial, 25 count, NDC 63323-0806-20
  • Fentanyl citrate solution for injection, Fresenius Kabi, 50 mcg/mL, 5 mL vial, 25 count, NDC 63323-0806-05
  • Fentanyl citrate solution for injection, Fresenius Kabi, 50 mcg/mL, 50 mL vial, 1 count, NDC 63323-0806-50
  • Fentanyl citrate solution for injection, Hikma, 50 mcg/mL, 1 mL vial, 25 count, NDC 00641-6247-25
  • Fentanyl citrate solution for injection, Hikma, 50 mcg/mL, 2 mL vial, 25 count, NDC 00641-6027-25
  • Fentanyl citrate solution for injection, Hikma, 50 mcg/mL, 20 mL vial, 1 count, NDC 00641-6029-01
  • Fentanyl citrate solution for injection, Hikma, 50 mcg/mL, 50 mL vial, 1 count, NDC 00641-6030-01
  • Fentanyl citrate solution for injection, Pfizer, 50 mcg/mL, 10 mL vial, 25 count, NDC 00409-9094-28
  • Fentanyl citrate solution for injection, Pfizer, 50 mcg/mL, 2 mL vial, 25 count, NDC 00409-9094-22
  • Fentanyl citrate solution for injection, Pfizer, 50 mcg/mL, 20 mL vial, 25 count, NDC 00409-9094-31
  • Fentanyl citrate solution for injection, Pfizer, 50 mcg/mL, 5 mL vial, 25 count, NDC 00409-9094-25
  • Fentanyl citrate solution for injection, Pfizer, 50 mcg/mL, 50 mL vial, 25 count, NDC 00409-9094-61

Estimated Resupply Dates

• • Hikma has fentanyl 50 mcg/mL 0.5 mL syringes on back order and the company cannot estimate a release date. There are short-dated 5 mL vials available with an expiration date of January 2025. There are short-dated 1 mL syringes available with an expiration date of March 2025.

Implications for Patient Care

• • ASHP has an FAQ on the injectable opioid shortage at https://www.ashp.org/Drug-Shortages/Shortage-Resources/Injectable-Opioid-Shortages-FAQ. This discusses multiple issues including inventory and pharmacy operational strategies