Calcium Disodium Versenate Injection Shortage

• • Calcium disodium versenate injection, Bausch Health, 200 mg/mL, 5 mL ampule, 5 count, NDC 99207-0240-05 - discontinued

• • Bausch Health discontinued calcium disodium versenate injection in June 2023.[1]
  • Rising Pharma launched edetate calcium disodium injection in mid-2023.[2]

• • Edetate calcium disodium injection, Rising Pharmaceuticals, 200 mg/mL, 5 mL vial, 5 count, NDC 64980-0588-51

Estimated Resupply Dates

• • Rising Pharma has edetate calcium disodium 200 mg/mL 5 mL vials available.[2]

Implications for Patient Care

• • Calcium disodium versenate is a chelation therapy used in both pediatric and adult lead poisonings.[3,4,5]

Alternative Agents & Management

• • Information on assessing lead poisonings and initiating chelation therapy can be found at https://www.cdc.gov/nceh/lead/advisory/acclpp/actions-blls.htm
  • During this shortage, consider succimer (DSMA) 10 mg/kg (350 mg/m2) orally every 8 hours for the first 5 days, then every 12 hours for 2 weeks (treatment duration of 19 days and maximum daily dose of 500 mg). Use caution in patients with renal impairment.[6,7,8]
  • Dosing may vary for different heavy metal poisonings. Contact your local clinical toxicologist or poison control center for patient-specific recommendations.

References

• 1. Bausch Health (personal communication): December 28, 2020; January 15, March 12, April 16, May 28, August 6, September 10, November 12, December 10, 2021; January 14, February 11, March 4 and 18, April 15 and 29, May 13, June 10, July 8 and 15, August 12, September 16 and 30, November 11, 2022; January 6, February 24, and May 5, 2023.
  2. Rising Pharma (personal communication). July 27, 2023.
  3. Calcium Disodium versenate - edetate calcium disodium injection [package insert]. Scottsdale, AZ: Medicis; 2012.
  4. Edetate Calcium Disodium. Drugdex System. IBM Micromedex [database online]. http://www.micromedexsolutions.com. Updated March 8, 2021. Greenwood Village, CO, USA: Truven Health Analytics; Accessed April 6, 2021.
  5. Howland M. Edetate Calcium Disodium (CaNa2Edta). In: Nelson LS, Howland M, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS. eds. Goldfrank's Toxicologic Emergencies. 11th ed. McGraw-Hill; Accessed April 6, 2021. https://accesspharmacy.mhmedical.com/content.aspx?bookid=2569&sectionid=210263402
  6. Succimer. Drugdex System. IBM Micromedex [database online]. http://micromedexsolutions.com. Updated July 27, 2020. Greenwood Village, CO: Truven Health Analytics; Accessed April 6, 2021.
  7. Succimer. Lexicomp Online. Hudson, OH: Wolters Kluwer Clinical Drug Information, Inc; 2018. http://online.lexi.com/. Updated March 12, 2021. Accessed April 6, 2021.
  8. Howland M. Succimer (2,3-Dimercaptosuccinic Acid) and Dmps (2,3-Dimercapto-1-Propanesulfonic Acid). In: Nelson LS, Howland M, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS. eds. Goldfrank's Toxicologic Emergencies, 11th ed. McGraw-Hill; Accessed April 06, 2021. https://accesspharmacy.mhmedical.com/content.aspx?bookid=2569&sectionid=210263346