Is it normal to still have nausea with Trintellix after over 2 months of taking it?

Both nausea and vomiting are common to very common side effects:
"Very common (10% or more of users): Nausea (up to 42%)
Common (1% to 10% of users): Abdominal discomfort, dry mouth, dyspepsia, flatulence, vomiting"
BUT, these side effects generally resolve with the first couple of weeks. If they persist longer than three weeks it should be brought to the attention of your doctor for a possible dosage reduction or switch to a different medication.
If your doctor allows you to continue on the drug despite the severity I'd get a 2nd opinion. Suffering for months or years is simply not necessary. There are other options.

Ok This is my experience. I have been 5mg of Trintellex. Still suffering from nausea without Zofran. I have been on it for over a year now. I get how you feel and dread every morning taken it. But do it anyway. Take care.

I have been on 20mg Trintellix for 8 or 9 years. I HAVE to take Zofran with it every day. Sometimes I still throw up but it is worth it. I was on Zoloft for many years and a few others. Nothing works for me like this drug. Unfortunately, I got a virus lately, and two weeks later, I'm still vomiting. I think my stomach might be kind of screwed up from taking Trintellix all the time. Trying to heal it with chicken soup Pepto, applesauce, yogurt, crackers, and ginger. Hoping it heals soon. Probably not giving up Trintellix but may need to for a few weeks

I couldn’t make it 2 months... I tried years ago and it worked so well but had to stop and after 20 plus years on most meds available I thought I’d give it another try being how well it did work but, it made me more sick this last time. I also have nausea meds phenergan and zofran and still couldn’t handle the nausea and vomiting. It worked great otherwise which is what stinks.

I have been on Trintellix for 4 yrs now, I was prescribed 10 mg but When starting any and I mean any new med I only take half,so I started with 5mg and it took about a 6-7 weeks before I stopped vomiting. The reason I kept on it was because it immediately gave me more energy and I was better able to function and once I threw up I was ok for the rest of the day. I bit the 5 mg in half because of the anxiety it causes, I slowly worked my way up 10mg last year because depression got worse but so did my home life. I am still very depressed but I live in a very abusive situation so I will try therapy again.My recommend cutting back on it for a while and see if that helps,also I recommend to listen to your own body instead of what doctor tells you because they will lie about the side effects because they are getting kickbacks from the drug companies.

I’m taking Trintellix; I was having nausea when I started taking it. I’v been on it for two years now and I very rarely have nausea now.
I always would have some saltines handy to nibble on for it. I never had any itching though.
Stay blessed.

So interesting that you say this. I’ve been on it for about 2 weeks give or take. At first I wasn't feeling nauseous. Maybe a little queasy but chalked it up to maybe a nervous feeling. But past few days super nauseous and have had to take zofran as well. I also have been extremely dizzy. When I stand up or sit down I get really light headed to the point I have to stop for a few a seconds until it passes . I was reading the label on the bottle this morning and it said may cause dizziness. I also looked it up and it said most common side effect was nausea. I can’t do this everyday so I’m calling my doctor today to have it switched ..

I have been taking Trintellix for 2 years now and after trying everything out there this one works best for me. I get nauseous every night when I take my 15mg but I know that if I stop taking it my life will be awful and the deep depression will set on quickly. I recently tried to take Prilosec OTC every morning and have noticed it has helped but might not be the answer for everyone. It’s so hard because this is the miracle drug for me and the nausea is a horrid side effect. I have tried anti nausea medicine which has helped but taste terrible. See if Prilosec or pepto helps.

I have been on Trintellix for about 3 years now. I have tried over 30 medications and it is the only antidepressant that has helped me. I, too have had to take zofran with it at the same time since day 1. It has been a great medication for me so the zofran is worth taking, plus it WORKS! I say, stick with it! I also take a good probiotic daily for my gut. - Hope this helps!

I too have severe nausea while taking Trintellix (20 mg). I have found that something as simple as sipping a couple of cups of hot herbal mint tea in the am after taking my medication makes me feel SO much better. My preference is a spearmint/peppermint blend.

Hi Courtney, I just started taking 5 mg of trintellix today and not even an hour goes by and I have been in the bathroom violently throwing up.. immediately I get online to find out the side effects and stumbled across your comment.. Now I don't know what to do I already take Wellbutrin and she was adding trintellix but if this is how I'm going to feel everyday then I just can't do this. When you made your comment it was back in 2017 I'm curious to know what has happened with you since then and if you have found an alternate method that worked for you. All the things I'm reading about it sounds very promising for my depression but I just don't know if I can deal with throwing up like I've been doing the last hour and a half.

I have been on Trintellix for a little over a month. I’m only taking 5mg. In just the past week I’ve had horrible nausea. Right now I’m holding back throwing up. It’s horrible. I’m calling my doctor tomorrow to see what I can do. I can’t take this anymore.

I had been talking Zofran along with 20 mg of Trintellix and learned that Zofran cancels in out, so it wasn't working as well. Now I am prescribed 25 mg of Phenergan 30 mins before I take the Trintellix at BEDTIME! It has been working wonderfully!

I have been on this medication for 8 weeks, gradually increasing & last week my dr increased it to 20mg. I’ve had nausea all along with this, but it goes. However, I feel so sick on 20mg, I also take mirtazapine at night. I have felt like throwing up a couple of times. I have tried so many different anti depressants & I this is finally helping. I am hoping the sickness dies down soon. My Dr had switched me to venlafaxine in Jan & that was horrendous. So not sure where to go from here if I can’t cope with the sickness.